杨立新，博士，副研究员。2015年中国科学院昆明动物研究所遗传学专业博士毕业，2015-2017年留在中国科学院昆明动物所比较基因组学实验室做助理研究员，从事人与非人灵长类大脑进化研究。2017-2018年在南方科技大学生物系从事博士后研究工作，研究M6A甲基化。2019年加入中国科学院深圳先进技术研究院，从事非人灵长类及啮齿类动物模型研究工作。主要研究内容涉及单基因遗传病动物模型制备及致病机制研究。先后以第一/通讯作者(含共同)在National Science Review，Advanced Science，Cerebral Cortex，Frontier In Psychiatry，Molecular Psychiatry，Neurobiology Of Disease，elife等杂志发表SCI学术论文11篇。

人与非人灵长类大脑进化及脑疾病的遗传机制研究；非人灵长类天然动物模型的筛选及脑疾病动物模型的构建等。

[1] 王虹, Miao Li, Lixin Yang. A novel rat model of Dravet syndrome recapitulates clinical hallmarks. Neurobiology of Disease[J]. 2023, [2] Zhuang, Mengru, Geng, Xiaoqi, Han, Peng, Che, Pengfei, Liang, Fanghao, Liu, Chao, Yang, Lixin, Yu, Jun, Zhang, Zhuxia, Dong, Wei, Ji, ShengJian. YTHDF2 in dentate gyrus is the m(6)A reader mediating m(6)A modification in hippocampus-dependent learning and memory. MOLECULAR PSYCHIATRY. 2023, http://dx.doi.org/10.1038/s41380-023-01953-z.

[3] Niu, Fugui, Che, Pengfei, Yang, Zhuoxuan, Zhang, Jian, Yang, Lixin, Zhuang, Mengru, Ou, Xijun, Ji, ShengJian. m(6)A regulation of cortical and retinal neurogenesis is mediated by the redundant m(6)A readers YTHDFs. ISCIENCE[J]. 2022, 25(9): http://dx.doi.org/10.1016/j.isci.2022.104908.

[4] Niu, Fugui, Han, Peng, Zhang, Jian, She, Yuanchu, Yang, Lixin, Yu, Jun, Zhuang, Mengru, Tang, Kezhen, Shi, Yuwei, Yang, Baisheng, Liu, Chunqiao, Peng, Bo, Ji, ShengJ, Mason, Carol A. The m(6)A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells. ELIFE[J]. 2022, 11: http://dx.doi.org/10.7554/eLife.75827.

[5] Jun Yu, Yuanchu She, Lixin Yang, Mengru Zhuang, Peng Han,, Jianhui Liu, Xiaoyan Lin, Nijia Wang, Mengxian Chen,, Sheng-Jian Ji. The m6A Readers YTHDF1 and YTHDF2 Synergistically Control Cerebellar Parallel Fiber Growth by Regulating Local Translation of the Key Wnt5a Signaling Components in Axons.. 2021